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PGRN as an emerging regulator of lipid metabolism in neurodegenerative diseases

2 Jun 2025

Abstract excerpt

Dysregulated lipid metabolism in microglia represents a hallmark of neuroinflammation and is often observed in a variety of neurodegenerative diseases. The exact molecular mechanisms underlying the induction of altered lipid homeostasis and how it contributes to neurodegeneration remain to be deciphered. Progranulin (PGRN) is a lysosomal glycoprotein encoded by GRN. Loss-of-function mutations or variants of GRN...

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Alcoholism and Thiamine Deficiency
Biochemical Acid Research Studies
Mitochondrial Function and Pathology

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40456955
DOI: 10.1038/s42003-025-08272-9

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