Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GPNMB, LRRK2, and lysosome exocytosis in Parkinson's.

Science advances - 19 Dec 2025

Pfeffer Suzanne R

Abstract excerpt

When two genes linked to increased Parkinson's risk converge on a lysosome, LRRK2 mutation enhances lysosomal release of soluble GPNMB potentially contributing to synuclein pathology.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Exocytosis
Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Share to Lysosomes
Share to Membrane Glycoproteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Parkinson Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 41406219
DOI: 10.1126/sciadv.aed8002
PMCID: PMC12710677

Genes

GPNMB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GPNMB, LRRK2, and lysosome exocytosis in Parkinson's.PMID 41406219Read ↗

GPNMB is a biomarker for lysosomal dysfunction and is secreted via LRRK2-modulated lysosomal exocytosisSemantic proximity Read ↗

The emerging role of LRRK2 in tauopathies.Semantic proximity Read ↗

Pro-cathepsin D, Prosaposin, and Progranulin: Lysosomal Networks in Parkinsonism.Semantic proximity Read ↗

Genetic perspective on the synergistic connection between vesicular transport, lysosomal and mitochondrial pathways associated with Parkinson’s disease pathogenesisSemantic proximity Read ↗

Common genetic risk for Parkinson's disease and dysfunction of the endo-lysosomal system.Semantic proximity Read ↗

Crosstalk between Lysosomes and Mitochondria in Parkinson's DiseaseSemantic proximity Read ↗

LRRK2 and Proteostasis in Parkinson's Disease.Semantic proximity Read ↗

Lysosomal Storage Disorders Shed Light on Lysosomal Dysfunction in Parkinson's Disease.Semantic proximity Read ↗

The role of glucocerebrosidase mutations in Parkinson disease and Lewy body disorders.Semantic proximity Read ↗

Role of the endolysosomal system in Parkinson’s diseaseSemantic proximity Read ↗

Advances in GBA-associated Parkinson's disease--Pathology, presentation and therapies.Semantic proximity Read ↗

LRRK2 at the interface of autophagosomes, endosomes and lysosomes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.