Article

Context-dependent effects of <i>CDKN2A</i> and other 9p21 gene losses during the evolution of oesophageal cancer

2024-01-26

Abstract excerpt

<h4>ABSTRACT</h4> CDKN2A is a tumour suppressor located in chromosome 9p21 and frequently lost in Barrett’s oesophagus (BO) and oesophageal adenocarcinoma (OAC). How CDKN2A and other 9p21 gene co-deletions affect OAC evolution remains understudied. We explored the effects of 9p21 loss in OACs and cancer progressor and non-progressor BOs with matched genomic, transcriptomic, and clinical data. Despite its cancer...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a2a5a069-6894-5a73-b935-d3ae43f708e4
DOI: 10.1101/2024.01.24.576991

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Context-dependent effects of <i>CDKN2A</i> and other 9p21 gene losses during the evolution of oesophageal cancerDOI 10.1101/2024.01.24.576991Read

Context-dependent effects of CDKN2A and other 9p21 gene losses during the evolution of esophageal cancerSemantic proximity Read

A multidimensional Pan-cancer analysis of CDKN1A identifies CDKN1A as an Immunological and Prognostic BiomarkerSemantic proximity Read

Patient-specific detection of cancer genes reveals recurrently perturbed processes in esophageal adenocarcinomaSemantic proximity Read

Concerted epithelial and stromal changes during progression of Barrett’s Esophagus to invasive adenocarcinoma exposed by multi-scale, multi-omics analysisSemantic proximity Read

Unraveling the pathogenesis of Barrett’s esophagus and esophageal adenocarcinoma: the “omics” eraSemantic proximity Read

Driver genes, mutational signatures and the timing of mutations in oesophageal adenocarcinomaSemantic proximity Read

Evolution and progression of Barrett's oesophagus to oesophageal cancer.Semantic proximity Read

AI-assisted Discovery of an Ethnicity-influenced Driver of Cell Transformation in Esophageal and Gastroesophageal Junction AdenocarcinomasSemantic proximity Read

Chromosome 9p21.3 Coordinates Cell Intrinsic and Extrinsic Tumor SuppressionSemantic proximity Read

Mutational signature dynamics shaping the evolution of oesophageal adenocarcinoma.Semantic proximity Read

Molecular Abnormalities and Carcinogenesis in Barrett’s Esophagus: Implications for Cancer Treatment and PreventionSemantic proximity Read

Key Genetic Determinants Driving Esophageal Squamous Cell Carcinoma Initiation and Immune EvasionSemantic proximity Read