Article

Driver genes, mutational signatures and the timing of mutations in oesophageal adenocarcinoma

2020-01-01

Abstract excerpt

The development of oesophageal adenocarcinoma (OAC) from Barrett's oesophagus provides an excellent model of the step-wise progression of malignancy. This process is strongly associated with the reflux of stomach contents into the oesophagus. However the exact mechanism by which low pH and bile acids contribute to the development of OAC remains unclear. The disease mostly presents late and treatment options are li...

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Literature Corpus work: 06918ffa-10bb-54e3-9632-da47d02b8a36
DOI: 10.17863/cam.45317

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