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Article

Context-dependent effects of CDKN2A and other 9p21 gene losses during the evolution of esophageal cancer

3 Jan 2025

Abstract excerpt

CDKN2A is a tumor suppressor located in chromosome 9p21 and frequently lost in Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC). How CDKN2A and other 9p21 gene co-deletions affect EAC evolution remains understudied. We explored the effects of 9p21 loss in EACs and cancer progressor and non-progressor BEs with matched genomic, transcriptomic and clinical data. Despite its cancer driver role, CDKN2A...

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PMID: 39753721
DOI: 10.1038/s43018-024-00876-0

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