Article

Chromosome 9p21.3 Coordinates Cell Intrinsic and Extrinsic Tumor Suppression

2022-08-23

Abstract excerpt

<h4>SUMMARY</h4> Somatic chromosomal deletions are prevalent in cancer, yet their functional contributions remain ill-defined. Among the most prominent of these events are deletions of chromosome 9p21.3, which disable a cell intrinsic barrier to tumorigenesis by eliminating the CDKN2A/B tumor suppressor genes. However, half of 9p21.3 deletions encompass a cluster of 16 type I interferons (IFNs) whose co-deletion...

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Literature Corpus work: 39377ac9-7f70-5440-b8d6-e575b0c0954a
DOI: 10.1101/2022.08.22.504793

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