Article

Key Genetic Determinants Driving Esophageal Squamous Cell Carcinoma Initiation and Immune Evasion

2022-10-17

Abstract excerpt

<h4>Background and aims</h4> Despite recent progress in identifying aberrant genetic and epigenetic alterations in esophageal squamous cell carcinoma (ESCC), the mechanism of ESCC initiation remains unknown. <h4>Methods</h4> Using CRISPR/Cas 9-based genetic ablation, we targeted 9 genes ( TP53 , CDKN2A , NOTCH1 , NOTCH3 , KMT2D , KMT2C , FAT1 , FAT4 , and AJUBA ) in murine esophageal organoids (EOs). Tr...

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Literature Corpus work: 3ffcb284-4eb7-5cb3-a843-ea347a19ed96
DOI: 10.1101/2022.10.13.512143

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