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Kinase impact assessment in the landscape of fusion genes that retain kinase domains: a pan-cancer study

16 Nov 2016

Abstract excerpt

Assessing the impact of kinase in gene fusion is essential for both identifying driver fusion genes (FGs) and developing molecular targeted therapies. Kinase domain retention is a crucial factor in kinase fusion genes (KFGs), but such a systematic investigation has not been done yet. To this end, we analyzed kinase domain retention (KDR) status in chimeric protein sequences of 914 KFGs covering 312 kinases across...

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PMID: 28013235
DOI: 10.1093/bib/bbw127

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