Mechanistic patterns and clinical implications of oncogenic tyrosine kinase fusions in human cancers

Abstract excerpt

<title>Abstract</title> <p>Tyrosine kinase (TK) fusions are frequently found in cancers, either as initiating events or as a mechanism of resistance to targeted therapy. Partner genes and exons in most TK fusions are typical and recurrent, but the underlying mechanisms and clinical implications of these patterns are poorly understood. Here, we investigated structures of > 8,000 kinase fusions and explore their ge...

Topics

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• Chronic Myeloid Leukemia Treatments
• Cytogenetic Analysis
• Gene Expression Regulation, Neoplastic
• Gene Fusion
• Gene Regulatory Networks
• Genetic Techniques
• Lung Cancer Treatments and Mutations
• PI3K/AKT/mTOR signaling in cancer

Identifiers and source

Literature Corpus work

d410e759-fe5b-5c56-8947-6f97d7b81718

DOI

10.21203/rs.3.rs-3782958/v1