Article

An <i>Engrailed1</i> enhancer underlies human thermoregulatory evolution

2020-08-23

Abstract excerpt

<h4>Summary</h4> Humans rely on sweating to cool off and have the highest eccrine sweat gland density among mammals. We investigated whether altered regulation of the Engrailed 1 ( EN1 ) gene, the levels of which are critical for patterning eccrine glands during development, could underlie the evolution of this defining human trait. First, we identify five EN1 candidate enhancers (ECEs) using comparative genom...

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Literature Corpus work: a281083f-0c67-5068-ae45-5c8d35da8f75
DOI: 10.1101/2020.08.22.262659

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