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Article

Selective sweep for an enhancer involucrin allele identifies skin barrier adaptation out of Africa.

Nature communications - 7 May 2021

Mathyer Mary Elizabeth, Brettmann Erin A, Schmidt Alina D, Goodwin Zane A, Oh Inez Y, Quiggle Ashley M, Tycksen Eric, Ramakrishnan Natasha, Matkovich Scot J, Guttman-Yassky Emma, Edwards John R, de Guzman Strong Cristina

Abstract excerpt

The genetic modules that contribute to human evolution are poorly understood. Here we investigate positive selection in the Epidermal Differentiation Complex locus for skin barrier adaptation in diverse HapMap human populations (CEU, JPT/CHB, and YRI). Using Composite of Multiple Signals and iSAFE, we identify selective sweeps for LCE1A-SMCP and involucrin (IVL) haplotypes associated with human migration...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33963188
DOI: 10.1038/s41467-021-22821-w
PMCID: PMC8105351

Genes

IVL
LCE1A
NFIC
SMCP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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