Article
Modeling recent human evolution in mice by expression of a selected EDAR variant.
Cell - 14 Feb 2013
Kamberov Yana G, Wang Sijia, Tan Jingze, Gerbault Pascale, Wark Abigail, Tan Longzhi, Yang Yajun, Li Shilin, Tang Kun, Chen Hua, Powell Adam, Itan Yuval, Fuller Dorian, Lohmueller Jason, Mao Junhao, Schachar Asa, Paymer Madeline, Hostetter Elizabeth, Byrne Elizabeth, Burnett Melissa, McMahon Andrew P, Thomas Mark G, Lieberman Daniel E, Jin Li, Tabin Clifford J, Morgan Bruce A, Sabeti Pardis C
Abstract excerpt
An adaptive variant of the human Ectodysplasin receptor, EDARV370A, is one of the strongest candidates of recent positive selection from genome-wide scans. We have modeled EDAR370A in mice and characterized its phenotype and evolutionary origins in humans. Our computational analysis suggests the allele arose in central China approximately 30,000 years ago. Although EDAR370A has been associated with increased...
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