Article

An enhancer:involucrin regulatory module impacts human skin barrier adaptation out-of-Africa and modifies atopic dermatitis risk

2019-11-05

Abstract excerpt

<h4>ABSTRACT</h4> The genetic modules that contribute to human evolution are poorly understood. We identified positive selection for two independent involucrin ( IVL ) haplotypes in European (CEU) and Asian (JPT/CHB) populations for skin epidermis. CEU IVL associated with increased IVL and a known epidermal-specific enhancer underwent a recent selective sweep out-of-Africa correlating with increased northern l...

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Literature Corpus work: bdf3085b-5dcd-581a-969e-9ef59e0fcafd
DOI: 10.1101/816520

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