Article
Repeated mutation of a developmental enhancer contributed to human thermoregulatory evolution.
Proceedings of the National Academy of Sciences of the United States of America - 20 Apr 2021
Aldea Daniel, Atsuta Yuji, Kokalari Blerina, Schaffner Stephen F, Prasasya Rexxi D, Aharoni Adam, Dingwall Heather L, Warder Bailey, Kamberov Yana G
Abstract excerpt
Humans sweat to cool their bodies and have by far the highest eccrine sweat gland density among primates. Humans' high eccrine gland density has long been recognized as a hallmark human evolutionary adaptation, but its genetic basis has been unknown. In humans, expression of the Engrailed 1 (EN1) transcription factor correlates with the onset of eccrine gland formation. In mice, regulation of ectodermal En1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.