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Article

Differential modularity of the mammalian Engrailed 1 enhancer network directs sweat gland development.

PLoS genetics - 1 Feb 2023

Aldea Daniel, Kokalari Blerina, Atsuta Yuji, Dingwall Heather L, Zheng Ying, Nace Arben, Cotsarelis George, Kamberov Yana G

Abstract excerpt

Enhancers are context-specific regulators of expression that drive biological complexity and variation through the redeployment of conserved genes. An example of this is the enhancer-mediated control of Engrailed 1 (EN1), a pleiotropic gene whose expression is required for the formation of mammalian eccrine sweat glands. We previously identified the En1 candidate enhancer (ECE) 18 cis-regulatory element that has...

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PMID: 36745673
DOI: 10.1371/journal.pgen.1010614
PMCID: PMC9934363

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