Article

Late onset of striatal projection neuron hyperexcitability in <i>Fmr1</i> -/y mice

2025-06-23

Abstract excerpt

<h4> Abstract </h4> Fragile X Syndrome (FXS), the most common genetic cause of intellectual disability and autism spectrum disorder (ASD), results from silencing of the FMR1 gene and consequent loss of Fragile X Messenger Ribonucleoprotein (FMRP). FMRP deficiency disrupts neural development, leading to behavioral and motor deficits associated with striatal dysfunction. While structural and functional abnormalit...

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Literature Corpus work: a2804612-55ff-5a7b-8f39-08537313fc9e
DOI: 10.1101/2025.06.21.660889

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