Article

Human-mouse chimeric Fragile X syndrome model reveals FMR1-dependent neuronal phenotypes

2020-10-26

Abstract excerpt

<title>Abstract</title> <p>Abnormal neuronal development in Fragile X syndrome (FXS) is poorly understood. Data on FXS patients remain scarce and FXS animal models have failed to yield successful therapies. In vitro models do not fully recapitulate the morphology and function of human neurons. Here, we co-injected neural precursor cells (NPCs) from FXS patient-derived and corrected isogenic control induced plurip...

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Literature Corpus work: af37cf62-b773-5ded-b6d9-c50001f2b015
DOI: 10.21203/rs.3.rs-83372/v1

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