Article

Dichotomous Intrinsic Properties of Adult Accumbens Medium Spiny Neurons Vanish in the Fragile X Mouse Model of Autism

2022-11-01

Abstract excerpt

<h4>Background: </h4> Fragile X syndrome (FXS), the most common monogenic cause of autism and inherited intellectual disability, is caused by the mutation of a single gene, Fmr1 , which encodes the Fragile X mental retardation protein (FMRP). FXS patients suffer from cognitive, emotional, and social deficits indicative of dysfunction in the nucleus accumbens (NAc), a structure central to the control of social beha...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 88d8d297-7c8a-5705-bde9-ac98fb5f1e56
DOI: 10.21203/rs.3.rs-2018294/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dichotomous Intrinsic Properties of Adult Accumbens Medium Spiny Neurons Vanish in the Fragile X Mouse Model of AutismDOI 10.21203/rs.3.rs-2018294/v1Read

Dichotomous Intrinsic Properties of Adult Accumbens Medium Spiny Neurons Vanish in the Fragile X Mouse Model of AutismSemantic proximity Read

Cell-Specific Disruptions in the Basolateral Amygdala-Accumbens Pathway of Fragile X mouseSemantic proximity Read

Late onset of striatal projection neuron hyperexcitability in <i>Fmr1</i> -/y miceSemantic proximity Read

Integrative analysis identifies key molecular signatures underlying neurodevelopmental deficits in fragile X syndromeSemantic proximity Read

Disrupted Hippocampal-Prefrontal Networks in a Rat Model of Fragile X Syndrome: A Study Linking Neural Dynamics to Autism-Like Behavioral ImpairmentsSemantic proximity Read

Fragile X syndrome patient-derived neurons developing in the mouse brain show <i>FMR1</i> -dependent phenotypesSemantic proximity Read

Cell type-specific disruption of cortico-striatal circuitry drives repetitive patterns of behaviour in fragile X syndrome model miceSemantic proximity Read

Fragile X Syndrome Patient-Derived Neurons Developing in the Mouse Brain Show FMR1-Dependent Phenotypes.Semantic proximity Read

The psychiatric presentation of fragile x: evolution of the diagnosis and treatment of the psychiatric comorbidities of fragile X syndrome.Semantic proximity Read

Multi-level profiling of the Fmr1 KO rat unveils altered behavioral traits along with aberrant glutamatergic functionSemantic proximity Read

Transcriptional dysregulation and impaired neuronal activity in <i>FMR1</i> knock-out and Fragile X patients’ iPSC-derived modelsSemantic proximity Read

A single-nucleus transcriptomic atlas of medium spiny neurons in the rat nucleus accumbensSemantic proximity Read