Article
Fragile X Syndrome Patient-Derived Neurons Developing in the Mouse Brain Show FMR1-Dependent Phenotypes.
Biological psychiatry - 1 Jan 2023
Krzisch Marine A, Wu Hao, Yuan Bingbing, Whitfield Troy W, Liu X Shawn, Fu Dongdong, Garrett-Engele Carrie M, Khalil Andrew S, Lungjangwa Tenzin, Shih Jennifer, Chang Aaron N, Warren Stephen, Cacace Angela, Andrykovich Kristin R, Rietjens Rosalie G J, Wallace Owen, Sur Mriganka, Jain Bhav, Jaenisch Rudolf
Abstract excerpt
BACKGROUND: Fragile X syndrome (FXS) is characterized by physical abnormalities, anxiety, intellectual disability, hyperactivity, autistic behaviors, and seizures. Abnormal neuronal development in FXS is poorly understood. Data on patients with FXS remain scarce, and FXS animal models have failed to yield successful therapies. In vitro models do not fully recapitulate the morphology and function of human neurons....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.