Article

Improvement of Behavioral Deficits in a Mouse Model of Fragile X Syndrome by Restoring α7 nAChR Hypofunction Associated with Aberrant Ly6H Expression

2024-11-03

Abstract excerpt

Fragile X Syndrome (FXS) is the most common form of inherited intellectual disability and often accompanied with debilitating pathologies including seizures and hyperactivity. FXS arises from a trinucleotide repeat expansion in the 5’ UTR of the FMR1 gene that silences expression of the RNA-binding protein FMRP. Despite progress in understanding FMRP functions, the identification of effective therapeutic targets...

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Literature Corpus work: 5a1e842c-62fa-51ea-9660-8d39ae3aa55a
DOI: 10.1101/2024.11.01.621616

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