Article

Altered axonal initial segment development links circuit and Kv7 dysfunction in an Fmr1 knockout rat

2026-08-23

Abstract excerpt

Fragile X syndrome (FXS) is the leading monogenetic cause of intellectual disability and autism, yet how basic hippocampal circuit properties evolve across development for this condition remains unclear. Here, we studied CA1 pyramidal neurons in male Fmr1 knockout rats at postnatal day (P)12 - 15 and 6 - 10 weeks using ex vivo electrophysiology pharmacology, imaging and biochemistry. P12 - 15 knockout neurons show...

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Literature Corpus work: 88223bea-4f34-5b27-bbbd-e1c8262d74b7
DOI: 10.64898/2026.08.18.745439

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