Article

A flexible summary-based colocalization method with application to the mucin Cystic Fibrosis lung disease modifier locus

2021-08-09

Abstract excerpt

Mucus obstruction is a central feature in the Cystic Fibrosis (CF) airways. A genome-wide association study (GWAS) of lung disease by the CF Gene Modifier Consortium (CFGMC) identified a significant locus containing two mucin genes, MUC20 and MUC4 . Expression quantitative trait locus (eQTL) analysis using human nasal epithelial (HNE) from 94 CF Canadians in the CFGMC demonstrated MUC4 eQTLs that mirrored the l...

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Literature Corpus work: a27a7e45-9c9a-517b-a6a7-199e0a72d696
DOI: 10.1101/2021.08.06.455333

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