Article
Colocalization of Gene Expression and DNA Methylation with Genetic Risk Variants Supports Functional Roles of MUC5B and DSP in Idiopathic Pulmonary Fibrosis.
American journal of respiratory and critical care medicine - 15 Nov 2022
Borie Raphael, Cardwell Jonathan, Konigsberg Iain R, Moore Camille M, Zhang Weiming, Sasse Sarah K, Gally Fabienne, Dobrinskikh Evgenia, Walts Avram, Powers Julie, Brancato Janna, Rojas Mauricio, Wolters Paul J, Brown Kevin K, Blackwell Timothy S, Nakanishi Tomoko, Richards J Brent, Gerber Anthony N, Fingerlin Tasha E, Sachs Norman, Pulit Sara L, Zappala Zachary, Schwartz David A, Yang Ivana V
Abstract excerpt
Rationale: Common genetic variants have been associated with idiopathic pulmonary fibrosis (IPF). Objectives: To determine functional relevance of the 10 IPF-associated common genetic variants we previously identified. Methods: We performed expression quantitative trait loci (eQTL) and methylation quantitative trait loci (mQTL) mapping, followed by co-localization of eQTL and mQTL with genetic association signals...
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