Article

A robust association test leveraging unknown genetic interactions: Application to cystic fibrosis lung disease

2023-06-24

Abstract excerpt

For complex traits such as lung disease in Cystic Fibrosis (CF), Gene x Gene or Gene x Environment interactions can impact disease severity but these remain largely unknown. Unaccounted-for genetic interactions introduce a distributional shift in the quantitative trait across the genotypic groups. Joint location and scale tests, or full distributional differences across genotype groups can account for unknown gene...

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Literature Corpus work: 9c0aad3c-0bd1-5b80-84bd-131ae62edba0
DOI: 10.1101/2023.06.22.546041

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