Article
A Joint Location-Scale Test Improves Power to Detect Associated SNPs, Gene Sets, and Pathways.
American journal of human genetics - 2 Jul 2015
Soave David, Corvol Harriet, Panjwani Naim, Gong Jiafen, Li Weili, Boëlle Pierre-Yves, Durie Peter R, Paterson Andrew D, Rommens Johanna M, Strug Lisa J, Sun Lei
Abstract excerpt
Gene-based, pathway, and other multivariate association methods are motivated by the possibility of GxG and GxE interactions; however, accounting for such interactions is limited by the challenges associated with adequate modeling information. Here we propose an easy-to-implement joint location-scale (JLS) association testing framework for single-variant and multivariate analysis that accounts for interactions...
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