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Article

A flexible summary statistics-based colocalization method with application to the mucin cystic fibrosis lung disease modifier locus.

American journal of human genetics - 3 Feb 2022

Wang Fan, Panjwani Naim, Wang Cheng, Sun Lei, Strug Lisa J

Abstract excerpt

Mucus obstruction is a central feature in the cystic fibrosis (CF) airways. A genome-wide association study (GWAS) of lung disease by the CF Gene Modifier Consortium (CFGMC) identified a significant locus containing two mucin genes, MUC20 and MUC4. Expression quantitative trait locus (eQTL) analysis using human nasal epithelia (HNE) from 94 CF-affected Canadians in the CFGMC demonstrated MUC4 eQTLs that mirrored...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35065708
DOI: 10.1016/j.ajhg.2021.12.012
PMCID: PMC8874229

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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