Sex and APOE ε4 genotype modify the Alzheimer's disease serum metabolome.

doi:10.1038/s41467-020-14959-w

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Article

Sex and APOE ε4 genotype modify the Alzheimer's disease serum metabolome.

Nature communications - 2 Mar 2020

Arnold Matthias, Nho Kwangsik, Kueider-Paisley Alexandra, Massaro Tyler, Huynh Kevin, Brauner Barbara, MahmoudianDehkordi Siamak, Louie Gregory, Moseley M Arthur, Thompson J Will, John-Williams Lisa St, Tenenbaum Jessica D, Blach Colette, Chang Rui, Brinton Roberta D, Baillie Rebecca, Han Xianlin, Trojanowski John Q, Shaw Leslie M, Martins Ralph, Weiner Michael W, Trushina Eugenia, Toledo Jon B, Meikle Peter J, Bennett David A, Krumsiek Jan, Doraiswamy P Murali, Saykin Andrew J, Kaddurah-Daouk Rima, Kastenmüller Gabi

Abstract excerpt

Late-onset Alzheimer's disease (AD) can, in part, be considered a metabolic disease. Besides age, female sex and APOE ε4 genotype represent strong risk factors for AD that also give rise to large metabolic differences. We systematically investigated group-specific metabolic alterations by conducting stratified association analyses of 139 serum metabolites in 1,517 individuals from the AD Neuroimaging Initiative...

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PMID: 32123170
DOI: 10.1038/s41467-020-14959-w
PMCID: PMC7052223

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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