Article

Nucleosome patterns in circulating tumor DNA reveal transcriptional regulation of advanced prostate cancer phenotypes

2022-06-25

Abstract excerpt

<h4>ABSTRACT</h4> Advanced prostate cancers comprise distinct phenotypes, but tumor classification remains clinically challenging. Here, we harnessed circulating tumor DNA (ctDNA) to study tumor phenotypes by ascertaining nucleosome positioning patterns associated with transcription regulation. We sequenced plasma ctDNA whole genomes from patient-derived xenografts representing a spectrum of androgen receptor act...

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Identifiers and source

Literature Corpus work: a23cf069-558e-5dba-9391-06222acd4dd0
DOI: 10.1101/2022.06.21.496879

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