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Plasma Cell-Free DNA Chromatin Immunoprecipitation Profiling Depicts Phenotypic and Clinical Heterogeneity in Advanced Prostate Cancer.

Cancer research - 17 Feb 2025

Sipola Joonatan, Munzur Aslı D, Kwan Edmond M, Seo Clara C Y, Hauk Benjamin J, Parekh Karan, Liao Yi Jou Ruby, Bernales Cecily Q, Donnellan Gráinne, Bloise Ingrid, Fung Emily, Ng Sarah W S, Wang Gang, Vandekerkhove Gillian, Nykter Matti, Annala Matti, Maurice-Dror Corinne, Chi Kim N, Herberts Cameron, Wyatt Alexander W, Takeda David Y

Abstract excerpt

Cell phenotype underlies prostate cancer presentation and treatment resistance and can be regulated by epigenomic features. However, the osteotropic tendency of prostate cancer limits access to metastatic tissue, meaning most prior insights into prostate cancer chromatin biology are from preclinical models that do not fully represent disease complexity. Noninvasive chromatin immunoprecipitation of histones in...

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PMID: 39652574
DOI: 10.1158/0008-5472.CAN-24-2052
PMCID: PMC11832346

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RB1

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