Article
Nucleosome Patterns in Circulating Tumor DNA Reveal Transcriptional Regulation of Advanced Prostate Cancer Phenotypes.
Cancer discovery - 1 Mar 2023
De Sarkar Navonil, Patton Robert D, Doebley Anna-Lisa, Hanratty Brian, Adil Mohamed, Kreitzman Adam J, Sarthy Jay F, Ko Minjeong, Brahma Sandipan, Meers Michael P, Janssens Derek H, Ang Lisa S, Coleman Ilsa M, Bose Arnab, Dumpit Ruth F, Lucas Jared M, Nunez Talina A, Nguyen Holly M, McClure Heather M, Pritchard Colin C, Schweizer Michael T, Morrissey Colm, Choudhury Atish D, Baca Sylvan C, Berchuck Jacob E, Freedman Matthew L, Ahmad Kami, Haffner Michael C, Montgomery R Bruce, Corey Eva, Henikoff Steven, Nelson Peter S, Ha Gavin
Abstract excerpt
Advanced prostate cancers comprise distinct phenotypes, but tumor classification remains clinically challenging. Here, we harnessed circulating tumor DNA (ctDNA) to study tumor phenotypes by ascertaining nucleosome positioning patterns associated with transcription regulation. We sequenced plasma ctDNA whole genomes from patient-derived xenografts representing a spectrum of androgen receptor active (ARPC) and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.