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Plasma epigenomic profiling reveals treatment-emergent squamous transformation in prostate cancer

9 Jul 2025

Abstract excerpt

Squamous transformation of prostate adenocarcinoma is a rare resistance mechanism in patients with advanced prostate cancer that impacts both prognosis and treatment. Herein, we profile circulating chromatin in serial plasma samples collected from a patient with metastatic prostate cancer that experienced squamous transformation. We detect dynamic changes in gene regulation from circulating chromatin reflecting...

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PMID: 40634667
DOI: 10.1038/s41698-025-01031-3

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