Article

Integrative genomic and epigenomic profiling in plasma and urinary cell-free DNA improves early risk stratification of newly diagnosed prostate cancer

2025-04-14

Abstract excerpt

<h4>Background and Objective</h4> Prostate cancer (PCa) is a heterogeneous disease, impeding early detection and risk stratification. Liquid biopsies (LBx) enable minimally invasive tumor profiling, but circulating tumor-derived DNA (ctDNA) detection remains difficult, especially in early-stage PCa. This study aimed at developing a multimodal LBx approach, analyzing genomic and epigenomic cell-free DNA (cfDNA) fea...

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Literature Corpus work: 7b9668e6-2065-588d-889e-d51e7f84db3a
DOI: 10.1101/2025.04.13.25325732

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