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Article

Massively parallel characterization of RNA G-quadruplex stability and molecular recognition.

Nucleic acids research - 24 Aug 2026

Martyr Justin G, Guzmán Bryan B, Jimenez Alli, Rothacher Rebekah L, Cavazos Francisco F, Hu Yue, Thompson Rhese D, Mustoe Anthony M, Aleman Maria M, Dominguez Daniel

Abstract excerpt

RNA G-quadruplexes (rG4s) have been implicated as important regulators of RNA metabolism and are promising targets for RNA-targeted therapeutics. rG4s typically require a canonical (G≥2N1-7)4 motif, but the sequence features that affect rG4 stability and recognition by RNA-binding proteins (RBPs) and rG4-binding ligands are not fully understood. To interrogate sequence-level drivers of rG4 folding, we applied a...

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Identifiers

PMID: 42635121
DOI: 10.1093/nar/gkag821
PMCID: PMC13501134

Genes

G3BP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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