Article

Single-Cell Mendelian Randomization Identifies Cell-Type Specific Genetic Drivers of Lung Cancer Subtypes

2025-12-02

Abstract excerpt

<h4>Background</h4> Genome-wide association studies (GWAS) have identified many loci linked to lung cancer, but connecting these loci to causal genes and relevant cell types remains difficult. Traditional Mendelian randomization (MR) using bulk tissue eQTLs averages signals across diverse cells, masking cell-specific effects. Here, we apply single-cell eQTL based MR to infer causal relationships at immune-cell re...

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Literature Corpus work: a210bd53-34ef-5a0e-8754-5f4893ba724a
DOI: 10.64898/2025.11.30.25341293

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