Article

A Statistical Framework to Identify Cell Types Whose Genetically Regulated Proportions are Associated with Complex Diseases

2021-03-10

Abstract excerpt

<title>Abstract</title> <p>Finding disease-relevant tissues and cell types can facilitate the identification and investigation of functional genes and variants. In particular, cell type proportions can serve as potential disease predictive biomarkers. Here, we introduce a novel statistical framework, cell-type Wide Association Study (cWAS), that integrates genetic data with transcriptomics data to identify cell t...

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Literature Corpus work: 53347db6-92ea-522d-9470-6e06d35249a8
DOI: 10.21203/rs.3.rs-275314/v1

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