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Article

Single-cell eQTL mapping reveals cell-type-specific genetic regulation in lung cancer.

Cell genomics - 11 Mar 2026

Fu Yating, Wang Yi, Jin Chen, Zhang Chang, Cai Jiaying, Gong Linnan, Jin Chenying, Ji Chen, Mou Yuanlin, Zhang Caochen, Wu Shihao, Ge Xinyuan, Dai Yahui, Miao Sunan, Ma Huimin, Ma Xiaoyang, Wang Mengping, Bian Lijun, Zhang Erbao, Dai Juncheng, Hu Zhibin, Jin Guangfu, Zhu Meng, Shen Hongbing, Ma Hongxia

Abstract excerpt

Genome-wide association studies (GWASs) have identified over 50 lung cancer risk loci; however, the precise cellular context of these genetic mechanisms remains unclear due to limitations in bulk tissue expression quantitative trait locus (eQTL) analyses. Here, we present the largest single-cell eQTL (sc-eQTL) atlas of human lung tissue to date, profiling 222 donors using multiplexed single-cell RNA sequencing...

Topics

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Carcinoma, Non-Small-Cell Lung
Gene Expression Regulation, Neoplastic
Genetic Predisposition to Disease
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Quantitative Trait Loci

Single-Cell Analysis

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Identifiers

PMID: 41386230
DOI: 10.1016/j.xgen.2025.101100
PMCID: PMC12985386

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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