Article

Context-aware single-cell multiome approach identified cell-type specific lung cancer susceptibility genes

2023-09-26

Abstract excerpt

<h4>Summary</h4> Genome-wide association studies (GWAS) identified over fifty loci associated with lung cancer risk. However, the genetic mechanisms and target genes underlying these loci are largely unknown, as most risk-associated-variants might regulate gene expression in a context-specific manner. Here, we generated a barcode-shared transcriptome and chromatin accessibility map of 117,911 human lung cells fro...

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Literature Corpus work: f10277f2-0d43-56a5-9293-aa7a79a12629
DOI: 10.1101/2023.09.25.559336

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