Bidirectional mendelian randomization and single-cell sequencing reveal T cell-mediated causal links between COPD and lung adenocarcinoma

Abstract excerpt

BACKGROUND: Chronic obstructive pulmonary disease (COPD) and lung cancer are the leading causes of lung disease-related deaths globally, sharing common risk factors like smoking. While COPD is known to increase lung cancer risk, the exact underlying mechanism remains unclear. We aim to explore the potential relationship between lung adenocarcinoma (LA) and COPD by application of Mendelian randomization analysis...

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