Article

Amyloid-β can activate JNK signalling via WNT-5A/ROR2 to reduce synapse formation in Alzheimer’s disease

2024-07-17

Abstract excerpt

Wnt signalling is an essential signalling system in neurogenesis, and recent studies have highlighted the critical role of this signalling network in regulating synaptic plasticity, neuronal survival, and neurogenesis, processes that are disrupted in Alzheimer’s disease (AD). From the Wnt network, the Wnt/β-catenin pathway has been studied for its neuroprotective role, and this is suppressed in AD. However, the in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 79d379d1-0db0-52d3-a2cb-b2b546fdf465
DOI: 10.1101/2024.07.16.603668

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Amyloid-β can activate JNK signalling via WNT-5A/ROR2 to reduce synapse formation in Alzheimer’s diseaseDOI 10.1101/2024.07.16.603668Read

Amyloid-β can activate JNK signalling via WNT5A-ROR2 to reduce synapse formation in Alzheimer's diseaseSemantic proximity Read

Age- and Sex-Associated Wnt Signaling Dysregulation is Exacerbated from the Early Stages of Neuropathology in an Alzheimer’s Disease ModelSemantic proximity Read

Dysregulated Wnt and NFAT signaling in a Parkinson’s disease LRRK2 G2019S knock-in modelSemantic proximity Read

Deficient Wnt Signaling and Synaptic Vulnerability in Alzheimer’s Disease: Emerging Roles for the LRP6 ReceptorSemantic proximity Read

Wnt signaling in the nervous system and in Alzheimer's diseaseSemantic proximity Read

Dysregulated Wnt and NFAT signaling in a Parkinson's disease LRRK2 G2019S knock-in model.Semantic proximity Read

Revealing Notch-dependencies in synaptic targets associated with Alzheimer’s diseaseSemantic proximity Read

Riluzole: a therapeutic strategy in Alzheimer’s disease by targeting the WNT/β-catenin pathwaySemantic proximity Read

RAPGEF2 mediates oligomeric Aβ-induced synaptic loss and cognitive dysfunction in Alzheimer’s diseaseSemantic proximity Read

Reversal of Synapse Degeneration by Restoring Wnt Signaling in the Adult HippocampusSemantic proximity Read

p75 Neurotrophin Receptor Shapes the Dynamics of Adult Hippocampal Neurogenesis in Alzheimer's DiseaseSemantic proximity Read

The Role of Reelin Signaling in Alzheimer’s DiseaseSemantic proximity Read