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Article

Hsp70 chaperone blocks α-synuclein oligomer formation via a novel engagement mechanism.

The Journal of biological chemistry - 1 Jan 2000

Tao Jiahui, Berthet Amandine, Citron Y Rose, Tsiolaki Paraskevi L, Stanley Robert, Gestwicki Jason E, Agard David A, McConlogue Lisa

Abstract excerpt

Overexpression and aggregation of α-synuclein (ASyn) are linked to the onset and pathology of Parkinson's disease and related synucleinopathies. Elevated levels of the stress-induced chaperone Hsp70 protect against ASyn misfolding and ASyn-driven neurodegeneration in cell and animal models, yet there is minimal mechanistic understanding of this important protective pathway. It is generally assumed that Hsp70...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33798554
DOI: 10.1016/j.jbc.2021.100613
PMCID: PMC8102405

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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