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Article

The role of HSP70 and its co-chaperones in protein misfolding, aggregation and disease.

Sub-cellular biochemistry - 1 Jan 2015

Duncan Emma J, Cheetham Michael E, Chapple J Paul, van der Spuy Jacqueline

Abstract excerpt

Molecular chaperones and their associated co-chaperones are essential in health and disease as they are key facilitators of protein folding, quality control and function. In particular, the HSP70 molecular chaperone networks have been associated with neurodegenerative diseases caused by aberrant protein folding. The pathogenesis of these disorders usually includes the formation of deposits of misfolded,...

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Identifiers

PMID: 25487025
DOI: 10.1007/978-3-319-11731-7_12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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