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Induction of Molecular Chaperones as a Therapeutic Strategy for the Polyglutamine Diseases

1 Feb 2010

Abstract excerpt

Protein misfolding and aggregation in the brain have been implicated as a common molecular pathogenesis of various neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and the polyglutamine (polyQ) diseases. The polyQ diseases are a group of nine hereditary neurodegenerative diseases, including Huntington's disease (HD) and various types of spinocerebellar...

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PMID: 20166962
DOI: 10.2174/138920110790909650

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