Article
On statistical modeling of sequencing noise in high depth data to assess tumor evolution
2017-04-19
Abstract excerpt
One cause of cancer mortality is tumor evolution to therapy-resistant disease. First line therapy often targets the dominant clone, and drug resistance can emerges from preexisting clones that gain fitness through therapy-induced natural selection. Such mutations may be identified using targeted sequencing assays by analysis of noise in high-depth data. Here, we develop a comprehensive, unbiased model for sequenci...
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Identifiers and source
- Literature Corpus work
- a1b72df6-9205-5967-832d-13acee98e8a5
- DOI
- 10.1101/128587