Article

A Generalized Evolutionary Classifier for Evolutionary Guided Precision Medicine

2020-09-25

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Current precision medicine (CPM) matches patients to therapies, utilizing traditional biomarker classifiers. Dynamic precision medicine (DPM) is an evolutionary guided precision medicine (EGPM) approach that specifically accounts for intratumoral genetic heterogeneity and evolutionary dynamics. DPM adapts as frequently as every six weeks, plans proactively for future resistanc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9733242a-9268-5b38-bad9-d4c8b7e33486
DOI: 10.1101/2020.09.24.20201111

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Generalized Evolutionary Classifier for Evolutionary Guided Precision MedicineDOI 10.1101/2020.09.24.20201111Read

Personalized cancer treatment strategies incorporating irreversible and reversible drug resistance mechanismsSemantic proximity Read

Tumor Evolution as a Therapeutic TargetSemantic proximity Read

Novel computational method for predicting polytherapy switching strategies to overcome tumor heterogeneity and evolutionSemantic proximity Read

Feasibility of an Evolutionary Tumor Board for Generating Novel Personalized Therapeutic StrategiesSemantic proximity Read

Probability Distribution for Rare Neutral Mutations in Cancers and Application to Dynamic Precision Medicine of CancerSemantic proximity Read

Feasibility of an Evolutionary Tumor Board for Generating Novel Personalized Therapeutic StrategiesSemantic proximity Read

Cancer Evolution and the Limits of Predictability in Precision Cancer MedicineSemantic proximity Read

Clone-level multi-modal prediction of tumour drug responseSemantic proximity Read

Liquid dynamic medicine and N-of-1 clinical trials: a change of perspective in oncology research.Semantic proximity Read

Computational quantification and characterization of independently evolving cellular subpopulations within tumors is critical to inhibit anti-cancer therapy resistanceSemantic proximity Read

Development of a dynamic counterfactual risk stratification strategy for newly diagnosed acute myeloid leukemia patients treated with venetoclax and azacitidineSemantic proximity Read

Programmed evolution: Using asexual gene drives to sculpt tumor populations and combat genetic diversitySemantic proximity Read