Natural selection is empirical risk minimisation

Abstract excerpt

<title>Abstract</title> <p>Drug resistance is responsible for the majority of cancer deaths, yet its evolutionary dynamics remain poorly predicted at treatment initiation. Here we show that resistance evolution timing across nine cancer types is predictable with \(\:r=0.96\) (\(\:p<0.0001\)) using a formula parameterized by two quantities already measured in standard clinical sequencing pipelines: intratumour het...

Topics

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• Algorithms
• Drug Design
• Drug Development
• Drug Resistance, Neoplasm
• Evolution, Molecular
• Genotype
• Models, Genetic
• Phenotype

Identifiers and source

Literature Corpus work

befb1928-e666-5692-9476-21c4bb5aacd7

DOI

10.21203/rs.3.rs-9848110/v1