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Quantitative measurement of phenotype dynamics during cancer drug resistance evolution using genetic barcoding

20 Jun 2025

Abstract excerpt

Cancer treatment frequently fails due to the evolution of drug-resistant cell phenotypes driven by genetic or non-genetic changes. The origin, timing, and rate of spread of these adaptations are critical for understanding drug resistance mechanisms but remain challenging to observe directly. We present a mathematical framework to infer drug resistance dynamics from genetic lineage tracing and population size data...

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PMID: 40541962
DOI: 10.1038/s41467-025-59479-7

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