Article

mGluR6 coordinates cone terminal targeting and synaptic layer assembly during human retinal development

2026-04-27

Abstract excerpt

<h4>SUMMARY</h4> The metabotropic glutamate receptor 6 (mGluR6), encoded by GRM6 , is a core component of the ON-bipolar signaling cascade in the retina, but its role in human retinal development remains unclear. Here, we used temporally controlled CRISPR-based genetic ablation in human induced pluripotent stem cell–derived retinal organoids to define the developmental functions of mGluR6. Unexpectedly, we found...

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Literature Corpus work: a1799361-8c0c-5357-bfde-c2cdec1b8a9f
DOI: 10.64898/2026.04.23.720451

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