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Article

LRIT3 Differentially Affects Connectivity and Synaptic Transmission of Cones to ON- and OFF-Bipolar Cells.

Investigative ophthalmology & visual science - 1 Mar 2017

Neuillé Marion, Cao Yan, Caplette Romain, Guerrero-Given Debbie, Thomas Connon, Kamasawa Naomi, Sahel José-Alain, Hamel Christian P, Audo Isabelle, Picaud Serge, Martemyanov Kirill A, Zeitz Christina

Abstract excerpt

Purpose: Mutations in LRIT3 lead to complete congenital stationary night blindness (cCSNB). Using a cCSNB mouse model lacking Lrit3 (nob6), we recently have shown that LRIT3 has a role in the correct localization of TRPM1 (transient receptor potential melastatin 1) to the dendritic tips of ON-bipolar cells (BCs), contacting both rod and cone photoreceptors. Furthermore, postsynaptic clustering of other mGluR6...

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Identifiers

PMID: 28334377
DOI: 10.1167/iovs.16-20745
PMCID: PMC5374884

Genes

TRPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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