Article

AAV-mediated generation of neurons in injury-induced and inherited retinal degenerations

2025-11-29

Abstract excerpt

Loss of retinal neurons is a leading cause of irreversible vision impairment, yet adult mammalian retinas lack the ability to regenerate these cells. In this study, we developed an adeno-associated virus (AAV)-based strategy to reprogram endogenous Müller glia into retinal neurons. Using stringent genetic lineage tracing, immunohistochemistry, electrophysiology and single-cell multiomic profiling, we show that AAV...

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Identifiers and source

Literature Corpus work: cd94e6da-45d5-57ca-b1c6-31c937ff181a
DOI: 10.1101/2025.11.28.688728

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