Article

Defective glycosylation and ELFN1 binding of mGluR6 congenital stationary night blindness mutants

2024-11-01

Abstract excerpt

Synaptic transmission from photoreceptors to ON-bipolar cells (BCs) requires the postsynaptic metabotropic glutamate receptor mGluR6, located at BC dendritic tips. Binding of the neurotransmitter glutamate initiates G-protein signaling that regulates the TRPM1 transduction channel. mGluR6 also interacts with presynaptic ELFN adhesion proteins, and these interactions are important for mGluR6 synaptic localization....

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Literature Corpus work: c32e365c-8afe-57ea-80e7-b5211b036142
DOI: 10.1101/2024.10.28.620767

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